Insulin Receptor Phosphorylation by Endogenous Insulin or the Insulin Analog AspB10 Promotes Mammary Tumor Growth Independent of the IGF-I Receptor

Endogenous hyperinsulinemia and insulin receptor (IR)/IGF-I receptor (IGF-IR) phosphorylation in tumors are associated with a worse prognosis in women with breast cancer. In vitro, insulin stimulation of the IR increases proliferation of breast cancer cells. However, in vivo studies demonstrating th...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Gallagher, Emily Jane, Alikhani, Nyosha, Tobin-Hess, Aviva, Blank, Jeffrey, Buffin, Nicholas J., Zelenko, Zara, Tennagels, Norbert, Werner, Ulrich, LeRoith, Derek
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Diabetes Association 2013
Pynciau:
Original Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3781483/
https://ncbi.nlm.nih.gov/pubmed/23835331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-0249
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