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OP449 Inhibits Human Breast Cancer Growth without Adverse Metabolic Effects
Hyperinsulinemia is associated with a decrease in breast cancer recurrence-free survival and overall survival. Inhibition of insulin receptor signaling is associated with glycemic dysregulation. SET is a direct modulator of PP2A, which negatively regulates the PI3K/Akt/mTOR pathway. OP449, a SET inh...
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| Publicat a: | Endocr Relat Cancer |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5678946/ https://ncbi.nlm.nih.gov/pubmed/28830934 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/ERC-17-0077 |
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