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OP449 Inhibits Human Breast Cancer Growth without Adverse Metabolic Effects

Hyperinsulinemia is associated with a decrease in breast cancer recurrence-free survival and overall survival. Inhibition of insulin receptor signaling is associated with glycemic dysregulation. SET is a direct modulator of PP2A, which negatively regulates the PI3K/Akt/mTOR pathway. OP449, a SET inh...

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書目詳細資料
發表在:Endocr Relat Cancer
Main Authors: Shlomai, Gadi, Zelenko, Zara, Antoniou, Irini Markella, Stasinopoulos, Marilyn, Tobin-Hess, Aviva, Vitek, Michael P., LeRoith, Derek, Gallagher, Emily Jane
格式: Artigo
語言:Inglês
出版: 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5678946/
https://ncbi.nlm.nih.gov/pubmed/28830934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/ERC-17-0077
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