Ebselen Treatment Prevents Islet Apoptosis, Maintains Intranuclear Pdx-1 and MafA Levels, and Preserves β-Cell Mass and Function in ZDF Rats

We reported earlier that β-cell–specific overexpression of glutathione peroxidase (GPx)-1 significantly ameliorated hyperglycemia in diabetic db/db mice and prevented glucotoxicity-induced deterioration of β-cell mass and function. We have now ascertained whether early treatment of Zucker diabetic f...

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Détails bibliographiques
Auteurs principaux: Mahadevan, Jana, Parazzoli, Susan, Oseid, Elizabeth, Hertzel, Ann V., Bernlohr, David A., Vallerie, Sara N., Liu, Chang-qin, Lopez, Melissa, Harmon, Jamie S., Robertson, R. Paul
Format: Artigo
Langue:Inglês
Publié: American Diabetes Association 2013
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3781455/
https://ncbi.nlm.nih.gov/pubmed/23801580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-0357
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