β-Cell-Specific Overexpression of Glutathione Peroxidase Preserves Intranuclear MafA and Reverses Diabetes in db/db Mice

Chronic hyperglycemia causes oxidative stress, which contributes to damage in various tissues and cells, including pancreatic β-cells. The expression levels of antioxidant enzymes in the islet are low compared with other tissues, rendering the β-cell more susceptible to damage caused by hyperglycemi...

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Main Authors: Harmon, Jamie S., Bogdani, Marika, Parazzoli, Susan D., Mak, Sabrina S. M., Oseid, Elizabeth A., Berghmans, Marleen, LeBoeuf, Renée C., Robertson, R. Paul
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775976/
https://ncbi.nlm.nih.gov/pubmed/19819955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2009-0708
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