Rolipram Attenuates Bile Duct Ligation–Induced Liver Injury in Rats: A Potential Pathogenic Role of PDE4

Anti-inflammatory and antifibrotic effects of the broad spectrum phosphodiesterase (PDE) inhibitor pentoxifylline have suggested an important role for cyclic nucleotides in the pathogenesis of hepatic fibrosis; however, studies examining the role of specific PDEs are lacking. Endotoxemia and Toll-li...

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Main Authors: Gobejishvili, Leila, Barve, Shirish, Breitkopf-Heinlein, Katja, Li, Yan, Zhang, JingWen, Avila, Diana V., Dooley, Steven, McClain, Craig J.
格式: Artigo
語言:Inglês
出版: The American Society for Pharmacology and Experimental Therapeutics 2013
主題:
Gastrointestinal, Hepatic, Pulmonary, and Renal
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3781411/
https://ncbi.nlm.nih.gov/pubmed/23887098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.113.204933
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