Tetrathiomolybdate Protects against Bile Duct Ligation-Induced Cholestatic Liver Injury and Fibrosis

Tetrathiomolybdate (TM), a potent copper-chelating drug, was initially developed for the treatment of Wilson’s disease. Our working hypothesis is that the fibrotic pathway is copper-dependent. Because biliary excretion is the major pathway for copper elimination, a bile duct ligation (BDL) mouse mod...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Song, Ming, Song, Zhenyuan, Barve, Shirish, Zhang, Jingwen, Chen, Theresa, Liu, Marcia, Arteel, Gavin E., Brewer, George J., McClain, Craig J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4222180/
https://ncbi.nlm.nih.gov/pubmed/18299419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.107.131227
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