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SB-205384 Is a Positive Allosteric Modulator of Recombinant GABA(A) Receptors Containing Rat α3, α5, or α6 Subunit Subtypes Coexpressed with β3 and γ2 Subunits

Many drugs used to treat anxiety are positive modulators of GABA(A) receptors, which mediate fast inhibitory neurotransmission. The GABA(A) receptors can be assembled from a combination of at least 16 different subunits. The receptor’s subunit composition determines its pharmacologic and functional...

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Библиографические подробности
Главные авторы: Heidelberg, Laura S., Warren, James W., Fisher, Janet L.
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Pharmacology and Experimental Therapeutics 2013
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3781410/
https://ncbi.nlm.nih.gov/pubmed/23902941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.113.207324
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