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A Novel Alcohol-Sensitive Position in the N-Methyl-d-Aspartate Receptor GluN2A Subunit M3 Domain Regulates Agonist Affinity and Ion Channel Gating

Abundant evidence supports a role for N-methyl-d-aspartate (NMDA) receptor inhibition in the behavioral actions of ethanol, but the underlying molecular mechanisms have not been fully elucidated. We recently found that clusters of five positions in the third and fourth membrane-associated domains (M...

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Bibliografske podrobnosti
Main Authors: Ren, Hong, Zhao, Yulin, Wu, Man, Peoples, Robert W.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Pharmacology and Experimental Therapeutics 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3781384/
https://ncbi.nlm.nih.gov/pubmed/23847085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.085993
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