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Two Adjacent Phenylalanines in the NMDA Receptor GluN2A Subunit M3 Domain Interactively Regulate Alcohol Sensitivity and Ion Channel Gating

The N-methyl-D-aspartate (NMDA) receptor is a key target of ethanol action in the central nervous system. Alcohol inhibition of NMDA receptor function involves small clusters of residues in the third and fourth membrane-associated (M) domains. Previous results from this laboratory have shown that tw...

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Publicat a:Neuropharmacology
Autors principals: Ren, Hong, Zhao, Yulin, Wu, Man, Dwyer, Donard S., Peoples, Robert W.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5240780/
https://ncbi.nlm.nih.gov/pubmed/27876530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2016.11.013
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