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Enantioselective Inhibition of Squalene Synthase by Aziridine Analogues of Presqualene Diphosphate
[Image: see text] Squalene synthase catalyzes the conversion of two molecules of (E,E)-farnesyl diphosphate to squalene via the cyclopropylcarbinyl intermediate, presqualene diphosphate (PSPP). Since this novel reaction constitutes the first committed step in sterol biosynthesis, there has been cons...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3781220/ https://ncbi.nlm.nih.gov/pubmed/20545375 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo100718z |
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