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Inhibition of monoterpene cyclases by inert analogues of geranyl diphosphate and linalyl diphosphate

The tightly coupled nature of the reaction sequence catalyzed by monoterpene synthases has prevented direct observation of the topologically required isomerization step leading from geranyl diphosphate to the enzyme-bound, tertiary allylic intermediate linalyl diphosphate, which then cyclizes to the...

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Bibliografische gegevens
Hoofdauteurs: Karp, Frank, Zhao, Yuxin, Santhamma, Bindu, Assink, Bryce, Coates, Robert M., Croteau, Rodney B.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2007
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2140145/
https://ncbi.nlm.nih.gov/pubmed/17949678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2007.09.008
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