Isopentenyl Diphosphate Isomerase. Mechanism-Based Inhibition by Diene Analogues of Isopentenyl Diphosphate and Dimethylallyl Diphosphate

Isopentenyl diphosphate isomerase (IDI) catalyzes the interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). This is an essential step in the mevalonate entry into the isoprenoid biosynthetic pathway. The isomerization catalyzed by type I IDI involves protonation of...

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Bibliographic Details
Main Authors: Wu, Zheng, Wouters, Johan, Poulter, C. Dale
Format: Artigo
Language:Inglês
Published: 2005
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2528281/
https://ncbi.nlm.nih.gov/pubmed/16332094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja056187h
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