Determination of kinetics and crystal structure of a novel Type 2 Isopentenyl Diphosphate: Dimethylallyl Diphosphate Isomerase from Streptococcus pneumoniae

Isopentenyl diphosphate dimethylallyl diphosphate isomerase (IDI) is a key enzyme in the isoprenoid biosynthetic pathway and is required for all organisms that synthesize isoprenoid metabolites from mevalonate. Type 1 IDI (IDI-1) is a metalloprotein and is found in eukaryotes, while the type-2 isofo...

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Main Authors: de Ruyck, Jerome, Janczak, Matthew W., Neti, Syam Sundar, Rothman, Steven C., Schubert, Heidi L., Cornish, Rita M., Matagne, Andre, Wouters, Johan, Poulter, C. Dale
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4215930/
https://ncbi.nlm.nih.gov/pubmed/24910111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201402046
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