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Exploring Symmetry as an Avenue to the Computational Design of Large Protein Domains

It was demonstrated previously that symmetric, homodimeric proteins are energetically favored, which explains their abundance in nature(1). It has been proposed that such symmetric homodimers underwent gene duplication and fusion to evolve into protein topologies that have a symmetric arrangement of...

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Autores principales: Fortenberry, Carie, Bowman, Elizabeth Anne, Proffitt, Will, Dorr, Brent, Combs, Steven, Harp, Joel, Mizoue, Laura, Meiler, Jens
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3781211/
https://ncbi.nlm.nih.gov/pubmed/21978247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja2051217
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