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Design of Native-Like Proteins through an Exposure-Dependent Environment Potential
We hypothesize that the degree of surface exposure of amino acid side chains within a globular, soluble protein has been optimized in evolution, not only to minimize the solvation free energy of the monomeric protein, but also to prevent protein aggregation. This effect needs to be taken into accoun...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3752783/ https://ncbi.nlm.nih.gov/pubmed/21905701 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200664b |
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