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Exploring Symmetry as an Avenue to the Computational Design of Large Protein Domains
It was demonstrated previously that symmetric, homodimeric proteins are energetically favored, which explains their abundance in nature(1). It has been proposed that such symmetric homodimers underwent gene duplication and fusion to evolve into protein topologies that have a symmetric arrangement of...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3781211/ https://ncbi.nlm.nih.gov/pubmed/21978247 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja2051217 |
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