Development of new N-Arylbenzamides as STAT3 Dimerization Inhibitors

The O-tosylsalicylamide S3I-201 (10) was used as a starting point for design and synthesis of novel STAT-3 dimerization inhibitors with improved drug-like qualities. The phosphonic acid 12d and salicylic acids 13f, 13g with a shorter amide linker lacking the O-tosyl group had improved STAT-3 inhibit...

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Huvudupphovsmän: Urlam, Murali K., Pireddu, Roberta, Ge, Yiyu, Zhang, Xiaolei, Sun, Ying, Lawrence, Harshani R., Guida, Wayne C., Sebti, Saïd M., Lawrence, Nicholas J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3780559/
https://ncbi.nlm.nih.gov/pubmed/24073326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C3MD20323A
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