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MOUSE MODELS FOR STUDYING PAIN IN SICKLE DISEASE: EFFECTS OF STRAIN, AGE, AND ACUTENESS

Clinical management of severe pain associated with sickle cell disease (SCD) remains challenging. Development of optimal therapy would be facilitated by use of murine model(s) with varying degrees of sickling and pain tests that are most sensitive to vasoocclusion. We found that young (≤3 month old)...

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Detalhes bibliográficos
Main Authors: Cain, David M., Vang, Derek, Simone, Donald A., Hebbel, Robert P., Gupta, Kalpna
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779783/
https://ncbi.nlm.nih.gov/pubmed/22171826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2141.2011.08977.x
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