Mast cell activation contributes to sickle cell pathobiology and pain in mice

Sickle cell anemia (SCA) is an inherited disorder associated with severe lifelong pain and significant morbidity. The mechanisms of pain in SCA remain poorly understood. We show that mast cell activation/degranulation contributes to sickle pain pathophysiology by promoting neurogenic inflammation an...

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Main Authors: Vincent, Lucile, Vang, Derek, Nguyen, Julia, Gupta, Mihir, Luk, Kathryn, Ericson, Marna E., Simone, Donald A., Gupta, Kalpna
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Hematology 2013
Ábhair:
Plenary Paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3772495/
https://ncbi.nlm.nih.gov/pubmed/23775718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-04-498105
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