Mast cell activation contributes to sickle cell pathobiology and pain in mice

Sickle cell anemia (SCA) is an inherited disorder associated with severe lifelong pain and significant morbidity. The mechanisms of pain in SCA remain poorly understood. We show that mast cell activation/degranulation contributes to sickle pain pathophysiology by promoting neurogenic inflammation an...

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Detalhes bibliográficos
Main Authors: Vincent, Lucile, Vang, Derek, Nguyen, Julia, Gupta, Mihir, Luk, Kathryn, Ericson, Marna E., Simone, Donald A., Gupta, Kalpna
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Plenary Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3772495/
https://ncbi.nlm.nih.gov/pubmed/23775718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-04-498105
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