Ebsulfur Is a Benzisothiazolone Cytocidal Inhibitor Targeting the Trypanothione Reductase of Trypanosoma brucei

Trypanosoma brucei is the causing agent of African trypanosomiasis. These parasites possess a unique thiol redox system required for DNA synthesis and defense against oxidative stress. It includes trypanothione and trypanothione reductase (TryR) instead of the thioredoxin and glutaredoxin systems of...

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Bibliographic Details
Main Authors: Lu, Jun, Vodnala, Suman K., Gustavsson, Anna-Lena, Gustafsson, Tomas N., Sjöberg, Birger, Johansson, Henrik A., Kumar, Sangit, Tjernberg, Agneta, Engman, Lars, Rottenberg, Martin E., Holmgren, Arne
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779740/
https://ncbi.nlm.nih.gov/pubmed/23900839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.495101
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