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Trypanosoma brucei Thymidine Kinase Is Tandem Protein Consisting of Two Homologous Parts, Which Together Enable Efficient Substrate Binding

Trypanosoma brucei causes African sleeping sickness, a disease for which existing chemotherapies are limited by their toxicity or lack of efficacy. We have found that four parasites, including T. brucei, contain genes where two or four thymidine kinase (TK) sequences are fused into a single open rea...

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Hlavní autoři: Ranjbarian, Farahnaz, Vodnala, Munender, Vodnala, Sharvani Munender, Rofougaran, Reza, Thelander, Lars, Hofer, Anders
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366807/
https://ncbi.nlm.nih.gov/pubmed/22442154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.340059
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