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Lung Fibrosis-associated Surfactant Protein A1 and C Variants Induce Latent Transforming Growth Factor β1 Secretion in Lung Epithelial Cells

Missense mutations of surfactant proteins are recognized as important causes of inherited lung fibrosis. Here, we study rare and common surfactant protein (SP)-A1 and SP-C variants, either discovered in our familial pulmonary fibrosis cohort or described by others. We show that expression of two SP-...

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Bibliografiske detaljer
Main Authors: Maitra, Meenakshi, Dey, Moushumi, Yuan, Wen-Cheng, Nathanielsz, Peter W., Garcia, Christine Kim
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779714/
https://ncbi.nlm.nih.gov/pubmed/23926107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.475335
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