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Mutant surfactant A2 proteins associated with familial pulmonary fibrosis and lung cancer induce TGF-β1 secretion

Mutations in the genes encoding the lung surfactant proteins are found in patients with interstitial lung disease and lung cancer, but their pathologic mechanism is poorly understood. Here we show that bronchoalveolar lavage fluid from humans heterozygous for a missense mutation in the gene encoding...

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Detalhes bibliográficos
Main Authors: Maitra, Meenakshi, Cano, Christopher A., Garcia, Christine Kim
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529022/
https://ncbi.nlm.nih.gov/pubmed/23223528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1217069110
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