Matrix Metalloproteinase-10/TIMP-2 Structure and Analyses Define Conserved Core Interactions and Diverse Exosite Interactions in MMP/TIMP Complexes

Matrix metalloproteinases (MMPs) play central roles in vertebrate tissue development, remodeling, and repair. The endogenous tissue inhibitors of metalloproteinases (TIMPs) regulate proteolytic activity by binding tightly to the MMP active site. While each of the four TIMPs can inhibit most MMPs, bi...

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Bibliographic Details
Main Authors: Batra, Jyotica, Soares, Alexei S., Mehner, Christine, Radisky, Evette S.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779175/
https://ncbi.nlm.nih.gov/pubmed/24073280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0075836
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