PEGylation Extends Circulation Half-Life While Preserving In Vitro and In Vivo Activity of Tissue Inhibitor of Metalloproteinases-1 (TIMP-1)

Excess proteolytic activity of matrix metalloproteinases (MMPs) contributes to the development of arthritis, cardiovascular diseases and cancer progression, implicating these enzymes as therapeutic targets. While many small molecule inhibitors of MMPs have been developed, clinical uses have been lim...

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Detalles Bibliográficos
Autores principales: Batra, Jyotica, Robinson, Jessica, Mehner, Christine, Hockla, Alexandra, Miller, Erin, Radisky, Derek C., Radisky, Evette S.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3502186/
https://ncbi.nlm.nih.gov/pubmed/23185522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050028
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