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PEGylation Extends Circulation Half-Life While Preserving In Vitro and In Vivo Activity of Tissue Inhibitor of Metalloproteinases-1 (TIMP-1)

Excess proteolytic activity of matrix metalloproteinases (MMPs) contributes to the development of arthritis, cardiovascular diseases and cancer progression, implicating these enzymes as therapeutic targets. While many small molecule inhibitors of MMPs have been developed, clinical uses have been lim...

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書誌詳細
主要な著者: Batra, Jyotica, Robinson, Jessica, Mehner, Christine, Hockla, Alexandra, Miller, Erin, Radisky, Derek C., Radisky, Evette S.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3502186/
https://ncbi.nlm.nih.gov/pubmed/23185522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050028
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