PEGylation Extends Circulation Half-Life While Preserving In Vitro and In Vivo Activity of Tissue Inhibitor of Metalloproteinases-1 (TIMP-1)

Excess proteolytic activity of matrix metalloproteinases (MMPs) contributes to the development of arthritis, cardiovascular diseases and cancer progression, implicating these enzymes as therapeutic targets. While many small molecule inhibitors of MMPs have been developed, clinical uses have been lim...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Batra, Jyotica, Robinson, Jessica, Mehner, Christine, Hockla, Alexandra, Miller, Erin, Radisky, Derek C., Radisky, Evette S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2012
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3502186/
https://ncbi.nlm.nih.gov/pubmed/23185522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050028
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk