Posttransplantation Systemic Immunomodulation with SA-FasL–Engineered Donor Splenocytes Has Robust Efficacy in Preventing Cardiac Allograft Rejection in Mice

Apoptosis induced by the engagement of FasL with Fas receptor on the surface of lymphocytes is an important immune homeostatic mechanism that ensures tolerance to self-antigens under normal physiologic conditions. As such, FasL has been extensively tested as a tolerogenic molecule with the use of ge...

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Main Authors: Zhao, H., Woodward, K. B., Shirwan, H., Grimany-Nuno, O., Yolcu, E. S.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779053/
https://ncbi.nlm.nih.gov/pubmed/23769048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.transproceed.2013.01.049
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