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Pancreatic islets engineered with a FasL protein induce systemic tolerance at the induction phase that evolves into long-term graft-localized immune privilege

We have previously shown that pancreatic islets engineered to transiently display a modified form of FasL protein (SA-FasL) on their surface survive indefinitely in allogeneic recipients without a need for chronic immunosuppression. Mechanisms that confer long-term protection to allograft are yet to...

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Detalhes bibliográficos
Publicado no:Am J Transplant
Main Authors: Woodward, Kyle Blake, Zhao, Hong, Shrestha, Pradeep, Batra, Lalit, Tan, Min, Grimany-Nuno, Orlando, Bandura-Morgan, Laura, Askenasy, Nadir, Shirwan, Haval, Yolcu, Esma S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7299172/
https://ncbi.nlm.nih.gov/pubmed/31850658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ajt.15747
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