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Posttransplantation Systemic Immunomodulation with SA-FasL–Engineered Donor Splenocytes Has Robust Efficacy in Preventing Cardiac Allograft Rejection in Mice
Apoptosis induced by the engagement of FasL with Fas receptor on the surface of lymphocytes is an important immune homeostatic mechanism that ensures tolerance to self-antigens under normal physiologic conditions. As such, FasL has been extensively tested as a tolerogenic molecule with the use of ge...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3779053/ https://ncbi.nlm.nih.gov/pubmed/23769048 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.transproceed.2013.01.049 |
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