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Human DNA helicase HELQ participates in DNA interstrand crosslink tolerance with ATR and RAD51 paralogs
Mammalian HELQ is a 3′–5′ DNA helicase with strand displacement activity. Here we show that HELQ participates in a pathway of resistance to DNA interstrand crosslinks (ICLs). Genetic disruption of HELQ in human cells enhances cellular sensitivity and chromosome radial formation by the ICL-inducing a...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Pub. Group
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3778836/ https://ncbi.nlm.nih.gov/pubmed/24005565 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3338 |
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