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HELQ promotes RAD51 paralog-dependent repair to avert germ cell attrition and tumourigenesis
Repair of interstrand crosslinks (ICLs) requires the coordinate action of the intra-S phase checkpoint and the Fanconi Anemia (FA) pathway, which promote ICL incision, translesion synthesis, and homologous recombination (reviewed in (1,2)). Previous studies have implicated the 3′-5′ superfamily 2 he...
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| Main Authors: | , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3836231/ https://ncbi.nlm.nih.gov/pubmed/24005329 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12565 |
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