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HELQ promotes RAD51 paralog-dependent repair to avert germ cell attrition and tumourigenesis

Repair of interstrand crosslinks (ICLs) requires the coordinate action of the intra-S phase checkpoint and the Fanconi Anemia (FA) pathway, which promote ICL incision, translesion synthesis, and homologous recombination (reviewed in (1,2)). Previous studies have implicated the 3′-5′ superfamily 2 he...

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Detalhes bibliográficos
Main Authors: Adelman, Carrie A., Lolo, Rafal L., Birkbak, Nicolai J., Murina, Olga, Matsuzaki, Kenichiro, Horejsi, Zuzana, Parmar, Kalindi, Borel, Valérie, Skehel, J. Mark, Stamp, Gordon, D’Andrea, Alan, Sartori, Alessandro A., Swanton, Charles, Boulton, Simon J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836231/
https://ncbi.nlm.nih.gov/pubmed/24005329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12565
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