HELQ promotes RAD51 paralog-dependent repair to avert germ cell attrition and tumourigenesis

Repair of interstrand crosslinks (ICLs) requires the coordinate action of the intra-S phase checkpoint and the Fanconi Anemia (FA) pathway, which promote ICL incision, translesion synthesis, and homologous recombination (reviewed in (1,2)). Previous studies have implicated the 3′-5′ superfamily 2 he...

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Autors principals: Adelman, Carrie A., Lolo, Rafal L., Birkbak, Nicolai J., Murina, Olga, Matsuzaki, Kenichiro, Horejsi, Zuzana, Parmar, Kalindi, Borel, Valérie, Skehel, J. Mark, Stamp, Gordon, D’Andrea, Alan, Sartori, Alessandro A., Swanton, Charles, Boulton, Simon J.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836231/
https://ncbi.nlm.nih.gov/pubmed/24005329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12565
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