EndoS(2) is a unique and conserved enzyme of serotype M49 group A Streptococcus that hydrolyses N-linked glycans on IgG and α(1)-acid glycoprotein

Many bacteria have evolved ways to interact with glycosylation functions of the immune system of their hosts. Streptococcus pyogenes [GAS (group A Streptococcus)] secretes the enzyme EndoS that cleaves glycans on human IgG and impairs the effector functions of the antibody. The ndoS gene, encoding E...

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Autori principali: Sjögren, Jonathan, Struwe, Weston B., Cosgrave, Eoin F. J., Rudd, Pauline M., Stervander, Martin, Allhorn, Maria, Hollands, Andrew, Nizet, Victor, Collin, Mattias
Natura: Artigo
Lingua:Inglês
Pubblicazione: Portland Press Ltd. 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3778708/
https://ncbi.nlm.nih.gov/pubmed/23865566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20130126
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