Targeted Disruption of the EZH2/EED Complex Inhibits EZH2-dependent Cancer

Enhancer of zeste homolog2 (EZH2) is the histone lysine N-methyltransferase component of the Polycomb repressive complex 2 (PRC2), which in conjunction with embryonic ectoderm development (EED) and suppressor of zeste 12 homolog (SUZ12), regulates cell lineage determination and homeostasis. Enzymati...

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Bibliografiske detaljer
Main Authors: Kim, Woojin, Bird, Gregory H., Neff, Tobias, Guo, Guoji, Kerenyi, Marc A., Walensky, Loren D., Orkin, Stuart H.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3778130/
https://ncbi.nlm.nih.gov/pubmed/23974116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1331
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