Pharmacological inhibition of noncanonical EED-EZH2 signaling overcomes chemoresistance in prostate cancer

Rationale: Chemoresistance is a major obstacle in prostate cancer (PCa) treatment. We sought to understand the underlying mechanism of PCa chemoresistance and discover new treatments to overcome docetaxel resistance. Methods: We developed a novel phenotypic screening platform for the discovery of sp...

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Publicat a:Theranostics
Autors principals: Li, Xin, Gera, Lajos, Zhang, Shumin, Chen, Yanhua, Lou, Lei, Wilson, Lauren Marie, Xie, Zhong-Ru, Sautto, Giuseppe, Liu, Degang, Danaher, Alira, Mamouni, Kenza, Yang, Yang, Du, Yuhong, Fu, Haian, Kucuk, Omer, Osunkoya, Adeboye O., Zhou, Jia, Wu, Daqing
Format: Artigo
Idioma:Inglês
Publicat: Ivyspring International Publisher 2021
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8171087/
https://ncbi.nlm.nih.gov/pubmed/34093859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.49235
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