SWI/SNF mutant cancers depend upon catalytic and non–catalytic activity of EZH2

Human cancer genome sequencing has recently revealed that genes encoding subunits of SWI/SNF chromatin remodeling complexes are frequently mutated across a wide variety of cancers, and several subunits of the complex have been shown to have bona fide tumor suppressor activity(1). However, whether mu...

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Detalhes bibliográficos
Publicado no:Nat Med
Main Authors: Kim, Kimberly H., Kim, Woojin, Howard, Thomas P., Vazquez, Francisca, Tsherniak, Aviad, Wu, Jennifer N., Wang, Weishan, Haswell, Jeffrey R., Walensky, Loren D., Hahn, William C., Orkin, Stuart H., Roberts, Charles W. M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4886303/
https://ncbi.nlm.nih.gov/pubmed/26552009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3968
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