SWI/SNF mutant cancers depend upon catalytic and non–catalytic activity of EZH2

Human cancer genome sequencing has recently revealed that genes encoding subunits of SWI/SNF chromatin remodeling complexes are frequently mutated across a wide variety of cancers, and several subunits of the complex have been shown to have bona fide tumor suppressor activity(1). However, whether mu...

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Udgivet i:Nat Med
Main Authors: Kim, Kimberly H., Kim, Woojin, Howard, Thomas P., Vazquez, Francisca, Tsherniak, Aviad, Wu, Jennifer N., Wang, Weishan, Haswell, Jeffrey R., Walensky, Loren D., Hahn, William C., Orkin, Stuart H., Roberts, Charles W. M.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4886303/
https://ncbi.nlm.nih.gov/pubmed/26552009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3968
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