Epithelial 11β-hydroxysteroid dehydrogenase type II deletion inhibits Apc(+/min) mouse tumorigenesis via COX-2 pathway inhibition and induction of G1 cell cycle arrest

Cyclooxygenase-2 (COX-2)-derived prostaglandin E(2) (PGE(2)) promotes colorectal tumorigenesis. Glucocorticoids are endogenous and potent COX-2 inhibitors, and their local actions are down-regulated by 11β–hydroxysteroid dehydrogenase type II (11ßHSD2)-mediated metabolism. We previously reported tha...

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Detalhes bibliográficos
Main Authors: Jiang, Li, Yang, Shilin, Yin, Huiyong, Fan, Xiaofeng, Wang, Suwan, Yao, Bing, Pozzi, Ambra, Chen, Xiaoping, Harris, Raymond C, Zhang, Ming-Zhi
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3778073/
https://ncbi.nlm.nih.gov/pubmed/23741059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-13-0084-T
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