טוען...
Epithelial 11β-hydroxysteroid dehydrogenase type II deletion inhibits Apc(+/min) mouse tumorigenesis via COX-2 pathway inhibition and induction of G1 cell cycle arrest
Cyclooxygenase-2 (COX-2)-derived prostaglandin E(2) (PGE(2)) promotes colorectal tumorigenesis. Glucocorticoids are endogenous and potent COX-2 inhibitors, and their local actions are down-regulated by 11β–hydroxysteroid dehydrogenase type II (11ßHSD2)-mediated metabolism. We previously reported tha...
שמור ב:
| Main Authors: | , , , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2013
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3778073/ https://ncbi.nlm.nih.gov/pubmed/23741059 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-13-0084-T |
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