Inhibition of 11β-Hydroxysteroid Dehydrogenase Type II Suppresses Lung Carcinogenesis by Blocking Tumor COX-2 Expression as Well as the ERK and mTOR Signaling Pathways

Lung cancer is by far the leading cause of cancer death. Early diagnosis and prevention remain the best approach to reduce the overall morbidity and mortality. Experimental and clinical evidence have shown that cyclooxygenase-2 (COX-2) derived prostaglandin E(2) (PGE2) contributes to lung tumorigene...

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Vydáno v:PLoS One
Hlavní autoři: Chang, Jian, Xue, Min, Yang, Shilin, Yao, Bing, Zhang, Bixiang, Chen, Xiaoping, Pozzi, Ambra, Zhang, Ming-Zhi
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4444260/
https://ncbi.nlm.nih.gov/pubmed/26011146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0127030
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