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Inhibition of mTOR Reduces Anal Carcinogenesis in Transgenic Mouse Model
The molecular mechanism of human anal squamous cell carcinoma (ASCC) is unclear, and the accumulating evidence indicate association of ASCC with the activation of the Akt/mTOR pathway. Here we describe a mouse model with spontaneous anal squamous cell cancer, wherein a combined deletion of Tgfbr1 an...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3790781/ https://ncbi.nlm.nih.gov/pubmed/24124460 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074888 |
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