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Inhibition of mTOR Reduces Anal Carcinogenesis in Transgenic Mouse Model

The molecular mechanism of human anal squamous cell carcinoma (ASCC) is unclear, and the accumulating evidence indicate association of ASCC with the activation of the Akt/mTOR pathway. Here we describe a mouse model with spontaneous anal squamous cell cancer, wherein a combined deletion of Tgfbr1 an...

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Detalhes bibliográficos
Main Authors: Sun, Zhi-Jun, Zhang, Lu, Zhang, Wei, Hall, Bradford, Bian, Yansong, Kulkarni, Ashok B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790781/
https://ncbi.nlm.nih.gov/pubmed/24124460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074888
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