Fragile Site Instability in Saccharomyces cerevisiae Causes Loss of Heterozygosity by Mitotic Crossovers and Break-Induced Replication

Loss of heterozygosity (LOH) at tumor suppressor loci is a major contributor to cancer initiation and progression. Both deletions and mitotic recombination can lead to LOH. Certain chromosomal loci known as common fragile sites are susceptible to DNA lesions under replication stress, and replication...

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Autores principales: Rosen, Danielle M., Younkin, Ellen M., Miller, Shaylynn D., Casper, Anne M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3778018/
https://ncbi.nlm.nih.gov/pubmed/24068975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003817
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