Hydrogen peroxide induced loss of heterozygosity correlates with replicative lifespan and mitotic asymmetry in Saccharomyces cerevisiae

Cellular aging in Saccharomyces cerevisiae can lead to genomic instability and impaired mitotic asymmetry. To investigate the role of oxidative stress in cellular aging, we examined the effect of exogenous hydrogen peroxide on genomic instability and mitotic asymmetry in a collection of yeast strain...

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Vydáno v:PeerJ
Hlavní autoři: Güven, Emine, Parnell, Lindsay A., Jackson, Erin D., Parker, Meighan C., Gupta, Nilin, Rodrigues, Jenny, Qin, Hong
Médium: Artigo
Jazyk:Inglês
Vydáno: PeerJ Inc. 2016
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5101604/
https://ncbi.nlm.nih.gov/pubmed/27833823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.2671
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