Remarkably Long-Tract Gene Conversion Induced by Fragile Site Instability in Saccharomyces cerevisiae

Replication stress causes breaks at chromosomal locations called common fragile sites. Deletions causing loss of heterozygosity (LOH) in human tumors are strongly correlated with common fragile sites, but the role of gene conversion in LOH at fragile sites in tumors is less well studied. Here, we in...

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Publicat a:Genetics
Autors principals: Chumki, Shahana A., Dunn, Mikael K., Coates, Thomas F., Mishler, Jeanmarie D., Younkin, Ellen M., Casper, Anne M.
Format: Artigo
Idioma:Inglês
Publicat: Genetics Society of America 2016
Matèries:
Investigations
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5012379/
https://ncbi.nlm.nih.gov/pubmed/27343237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.116.191205
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