Activation of Ran GTPase by a Legionella Effector Promotes Microtubule Polymerization, Pathogen Vacuole Motility and Infection

The causative agent of Legionnaires' disease, Legionella pneumophila, uses the Icm/Dot type IV secretion system (T4SS) to form in phagocytes a distinct “Legionella-containing vacuole” (LCV), which intercepts endosomal and secretory vesicle trafficking. Proteomics revealed the presence of the sm...

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Hauptverfasser: Rothmeier, Eva, Pfaffinger, Gudrun, Hoffmann, Christine, Harrison, Christopher F., Grabmayr, Heinrich, Repnik, Urska, Hannemann, Mandy, Wölke, Stefan, Bausch, Andreas, Griffiths, Gareth, Müller-Taubenberger, Annette, Itzen, Aymelt, Hilbi, Hubert
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3777869/
https://ncbi.nlm.nih.gov/pubmed/24068924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003598
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