The Legionella longbeachae Icm/Dot Substrate SidC Selectively Binds Phosphatidylinositol 4-Phosphate with Nanomolar Affinity and Promotes Pathogen Vacuole-Endoplasmic Reticulum Interactions

Legionella spp. cause the severe pneumonia Legionnaires' disease. The environmental bacteria replicate intracellularly in free-living amoebae and human alveolar macrophages within a distinct, endoplasmic reticulum (ER)-derived compartment termed the Legionella-containing vacuole (LCV). LCV form...

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Main Authors: Dolinsky, Stephanie, Haneburger, Ina, Cichy, Adam, Hannemann, Mandy, Itzen, Aymelt, Hilbi, Hubert
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2014
Teme:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187854/
https://ncbi.nlm.nih.gov/pubmed/25024371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01685-14
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