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A Chemogenomic Analysis of Ionization Constants - Implications for Drug Discovery

Chemogenomics methods seek to characterize the interaction between drugs and biological systems and are an important guide for the selection of screening compounds. The acid/base character of drugs has a profound influence on their affinity for the receptor, on their absorption, distribution, metabo...

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Bibliografiska uppgifter
Huvudupphovsmän: Manallack, David T., Prankerd, Richard J., Nassta, Gemma C., Ursu, Oleg, Oprea, Tudor I., Chalmers, David K.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3777741/
https://ncbi.nlm.nih.gov/pubmed/23303535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201200507
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