PPARγ-mediated increase in glucose availability sustains chronic Brucella abortus infection in alternatively activated macrophages

Eradication of persistent intracellular bacterial pathogens with antibiotic therapy is often slow or incomplete. However, strategies to augment antibiotics are hampered by our poor understanding of the nutritional environment that sustains chronic infection. Here we show that the intracellular patho...

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Main Authors: Xavier, Mariana N., Winter, Maria G., Spees, Alanna M., den Hartigh, Andreas B., Nguyen, Kim, Roux, Christelle M., Silva, Teane M. A., Atluri, Vidya L., Kerrinnes, Tobias, Keestra, A. Marijke, Monack, Denise M., Luciw, Paul A., Eigenheer, Richard A., Bäumler, Andreas J., Santos, Renato L., Tsolis, Renée M.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3777723/
https://ncbi.nlm.nih.gov/pubmed/23954155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2013.07.009
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